Resolution of an Infection with Leishmania braziliensis Confers Complete Protection to a Subsequent Challenge with Leishmania major in BALB/c Mice
Both Leishmania major and L. braziliensis induce cutaneous leishmaniasis in BALB/c mice. Whereas BALB/c mice die of infection with L. major, they cure an infection with L. braziliensis. We report here that after curing an infection with L. braziliensis, BALB/c mice are resistant to challenge with L....
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Veröffentlicht in: | Memórias do Instituto Oswaldo Cruz 1999-01, Vol.94 (1), p.71-76 |
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Zusammenfassung: | Both Leishmania major and L. braziliensis induce cutaneous
leishmaniasis in BALB/c mice. Whereas BALB/c mice die of infection with
L. major, they cure an infection with L. braziliensis. We report here
that after curing an infection with L. braziliensis, BALB/c mice are
resistant to challenge with L. major. When challenged with L. major, L.
braziliensis pre-treated BALB/c mice mounted a delayed-type
hypersensitivity response to L. major and produced high amounts of
interferon -γ (IFN-γ) but low amounts of interleukin-4. The
IFN-γ produced by the L. braziliensis pre-infected mice was
involved in the protection seen against L. major challenge since
treating the mice with a neutralizing anti-IFN-γ abrogated the
protection. This suggests that cross-reactive antigen epitopes exist
between L. braziliensis and L. major and that pre-infection with L.
braziliensis primes BALB/c mice to epitopes on L. major that can elicit
a protective Th1 response to the parasite. |
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ISSN: | 1678-8060 0074-0276 0074-0276 1678-8060 |
DOI: | 10.1590/S0074-02761999000100015 |