Reduced Lysosomal Acid Lipase Activity in Adult Patients With Non-alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is characterized by intra-hepatic fat accumulation and mechanisms involved in its pathogenesis are not fully explained. Lysosomal Acid Lipase (LAL) is a key enzyme in lipid metabolism. We investigated its activity in patients with fatty liver. LAL activity (...

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Veröffentlicht in:	EBioMedicine 2015-07, Vol.2 (7), p.750-754
Hauptverfasser:	Baratta, Francesco, Pastori, Daniele, Del Ben, Maria, Polimeni, Licia, Labbadia, Giancarlo, Di Santo, Serena, Piemonte, Fiorella, Tozzi, Giulia, Violi, Francesco, Angelico, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Case-Control Studies Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Logistic Models Lysosomal acid lipase Male Metabolic syndrome Middle Aged Multivariate Analysis Non-alcoholic fatty liver disease Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - enzymology Non-alcoholic steatohepatitis Original Statins Sterol Esterase - metabolism
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Zusammenfassung:	Non-alcoholic fatty liver disease (NAFLD) is characterized by intra-hepatic fat accumulation and mechanisms involved in its pathogenesis are not fully explained. Lysosomal Acid Lipase (LAL) is a key enzyme in lipid metabolism. We investigated its activity in patients with fatty liver. LAL activity (nmol/spot/h) was measured in 100 adult healthy subjects (HS) and in 240 NAFLD patients. A sub-analysis on 35 patients with biopsy-proven non-alcoholic steatohepatitis (NASH) was performed. Median LAL activity was 1.15 (0.95–1.72) in HS. It was significantly reduced in NAFLD [0.78 (0.61–1.01), p
ISSN:	2352-3964 2352-3964
DOI:	10.1016/j.ebiom.2015.05.018