Micromechanical adaptation as a treatment for spinal cord injury

Spinal cord injury: [...]far injury of the spinal cord is incurable and, in the majority of cases, a devastating and life-changing event. The characteristic surface structure was achieved by an advanced silicon etching process for the side walls of the silicone mold ensuring optimal adherence of the tissue to the mMS walls after implantation and negative pressure application.Internal supply system: When screening SCI literature it becomes obvious that maximum (Basso, Beattie, Breshnahan) BBB open field scores of rats with complete spinal cord transection generally range between BBB 0 (no observable hind limb movement) and BBB 3 (extensive movement of two joints of the hind limbs) for untreated control animals, and at maximum between BBB 6 (extensive movement of two joints and slight movement of the third) to BBB 8 (sweeping with no weight support/plantar placement of the paw with no weight support) for animals, which received some more or less effective treatment. The mMS implantation after complete spinal cord injury of the rat resulted in a thus far unmet locomotor functional recovery up to a BBB score of 10 (occasional weight supported plantar steps, no coordination) to 11 (frequent to consistent weight supported plantar steps and no forelimb-hindlimb coordination) (Estrada et al., 2018b).