171 : Efficacy of Kidscore in Predicting Ongoing Pregnancy Rate and Miscarriage Rate

Background and Aims: EmbryoScope+ scoring (KIDScore TM) has been shown to improve embryo selection based on morphology and morphokinetics assessment. Prediction of clinical pregnancy rates based on KIDScoreTM achieved different outcomes across IVF clinics. This study aims to assess the efficacy of KIDScoreTM in predicting clinical outcomes for single euploid blastocyst transfer in Alpha IVF. Method: This retrospective study analyzed the clinical outcomes of 349 patients (mean age 33.9) undergoing frozen-thawed single euploid blastocyst transfer from August 2020 to September 2022. All blastocysts were annotated with a KIDScoreTM value prior to biopsy and further categorized into 9 groups (1.0-1.9, 2.0-2.9, 3.0-3.9, 4.0-4.9, 5.0-5.9, 6.0-6.9, 7.0-7.9, 8.0-8.9, 9.0-9.9). Clinical pregnancy and number of gestational sacs were determined by ultrasound. Logistic regression was used to calculate the coefficient of determination (R2). Results: Out of 349 single euploid blastocyst transfer, 251(72%) achieved clinical pregnancy. Coefficient of determination from the regression model showed that the clinical pregnancy rate was weakly correlated with KIDScoreTM value (R2=0.2851). 64.96% of the rising trend in the ongoing pregnancy rate can be correlated with KIDScoreTM value. The data also showed a declining trend in miscarriage rate as the KIDScoreTM value increased, of which 77.82% of the events can be predicted accurately by KIDScoreTM value. Conclusion: KIDScoreTM value appears to be a good predictor for ongoing pregnancy rate and miscarriage rate. However, we are cautious in making this statement as most of the selected blastocysts for transfer are from a higher KIDScoreTM group. Assessment on the efficacy of KIDScoreTM in predicting clinical outcomes can be conducted with further blastocysts’ classification. (251 words)