A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries

FoxO1 is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. FoxO1 controls the transcription of downstream genes mediating metabolic regulation. Dysfunction of FoxO1 pathways...

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Veröffentlicht in:	Cells (Basel, Switzerland) Switzerland), 2020-01, Vol.9 (1), p.184
Hauptverfasser:	Peng, Shiming, Li, Wei, Hou, Nannan, Huang, Niu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Animal behavior Arteriosclerosis Atherosclerosis Diabetes mellitus DNA methylation drug discovery Energy metabolism Fatty liver Food foxo1 FOXO1 protein Gene regulation Genes Glucose Hypothalamus Insulin resistance Kinases Lipoproteins Liver Liver diseases metabolic disease Metabolic disorders Obesity Phosphorylation Proteins Regulation Review Thermogenesis Tumors
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Beschreibung
Zusammenfassung:	FoxO1 is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. FoxO1 controls the transcription of downstream genes mediating metabolic regulation. Dysfunction of FoxO1 pathways results in several metabolic diseases, including diabetes, obesity, non-alcoholic fatty liver disease, and atherosclerosis. Here, we summarize the mechanism of FoxO1 regulation behind these diseases and FoxO1-related drug discoveries.
ISSN:	2073-4409 2073-4409
DOI:	10.3390/cells9010184