Quinine-resistant malaria in traveler returning from Senegal, 2007

We describe clinical and parasitologic features of in vivo and in vitro Plasmodium falciparum resistance to quinine in a nonimmune traveler who returned to France from Senegal in 2007 with severe imported malaria. Clinical quinine failure was associated with a 50% inhibitory concentration of 829 nmo...

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Veröffentlicht in:	Emerging infectious diseases 2010-03, Vol.16 (3), p.546-548
Hauptverfasser:	Pradines, Bruno, Pistone, Thierry, Ezzedine, Khaled, Briolant, Sebastien, Bertaux, Lionel, Receveur, Marie Catherine, Parzy, Daniel, Millet, Pascal, Rogier, Christophe, Malvy, Denis
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antimalarials - administration & dosage Antimalarials - pharmacology Care and treatment Dispatch Drug Resistance France Humans Malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology Male parasites Parasitic Sensitivity Tests Plasmodium falciparum Plasmodium falciparum - drug effects Quinine Quinine - administration & dosage Quinine - pharmacology Senegal Travel Travelers
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Zusammenfassung:	We describe clinical and parasitologic features of in vivo and in vitro Plasmodium falciparum resistance to quinine in a nonimmune traveler who returned to France from Senegal in 2007 with severe imported malaria. Clinical quinine failure was associated with a 50% inhibitory concentration of 829 nmol/L. Increased vigilance is required during treatment follow-up.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1603.091669