Comparison of the performance of currently used estimated glomerular filtration rate equations with 24-hour urine creatinine clearance: sample analysis of randomised controlled trial participants

ObjectiveThere are several equations for estimating the glomerular filtration rate (GFR), and each method has its limitations. We compared various estimated GFR (eGFR) equations with 24 hours urine creatinine clearance (24u-CCr).DesignSample analysis of randomised controlled trial participants.Setting and participantsWe compared the mean 24u-CCr values measured 2–3 times for 211 patients with eGFR values calculated using the following equations: isotope dilution mass spectrometry-Modification of Diet in Renal Disease (IDMS-MDRD) equation, Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation, equations for Koreans (KOR-IDMS-MDRD and KOR-CKD-EPI) and full age spectrum equation.Outcome measuresPerformance of various creatinine-based eGFR equations, including those with Korean coefficients, compared with the results of the 24u-CCr.ResultsIDMS-MDRD showed the best overall correlation with the 24u-CCr (R=0.949, p