Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes: cohort study of 151 141 singleton pregnancies

ObjectivesTo identify any associations between in utero exposure to five over-the-counter (non-prescription) analgesics (paracetamol, ibuprofen, aspirin, diclofenac, naproxen) and adverse neonatal outcomes.DesignRetrospective cohort study using the Aberdeen Maternity and Neonatal Databank.Participan...

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Veröffentlicht in:	BMJ open 2022-05, Vol.12 (5), p.e048092
Hauptverfasser:	Zafeiri, Aikaterini, Raja, Edwin Amalraj, Mitchell, Rod Thomas, Hay, David C, Bhattacharya, Sohinee, Fowler, Paul A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Analgesics Analgesics - adverse effects Apgar score Aspirin Birth defects Birth Weight clinical pharmacology Cohort analysis Cohort Studies Cryptorchidism Epidemiology Female Humans Hypertension Hypospadias Infant, Newborn Male Nonsteroidal anti-inflammatory drugs obstetrics Perinatal Death Pregnancy Pregnancy Outcome - epidemiology Premature birth Premature Birth - epidemiology Retrospective Studies Stillbirth - epidemiology Variables Womens health
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Zusammenfassung:	ObjectivesTo identify any associations between in utero exposure to five over-the-counter (non-prescription) analgesics (paracetamol, ibuprofen, aspirin, diclofenac, naproxen) and adverse neonatal outcomes.DesignRetrospective cohort study using the Aberdeen Maternity and Neonatal Databank.Participants151 141 singleton pregnancies between 1985 and 2015.Main outcome measuresPremature delivery (
ISSN:	2044-6055 2044-6055
DOI:	10.1136/bmjopen-2020-048092