Quantifying the effect of nutritional interventions on metabolic resilience using personalized computational models

The manifestation of metabolic deteriorations that accompany overweight and obesity can differ greatly between individuals, giving rise to a highly heterogeneous population. This inter-individual variation can impede both the provision and assessment of nutritional interventions as multiple aspects...

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Veröffentlicht in:iScience 2024-04, Vol.27 (4), p.109362-109362, Article 109362
Hauptverfasser: O’Donovan, Shauna D., Rundle, Milena, Thomas, E. Louise, Bell, Jimmy D., Frost, Gary, Jacobs, Doris M., Wanders, Anne, de Vries, Ryan, Mariman, Edwin C.M., van Baak, Marleen A., Sterkman, Luc, Nieuwdorp, Max, Groen, Albert K., Arts, Ilja C.W., van Riel, Natal A.W., Afman, Lydia A.
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Sprache:eng
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Zusammenfassung:The manifestation of metabolic deteriorations that accompany overweight and obesity can differ greatly between individuals, giving rise to a highly heterogeneous population. This inter-individual variation can impede both the provision and assessment of nutritional interventions as multiple aspects of metabolic health should be considered at once. Here, we apply the Mixed Meal Model, a physiology-based computational model, to characterize an individual’s metabolic health in silico. A population of 342 personalized models were generated using data for individuals with overweight and obesity from three independent intervention studies, demonstrating a strong relationship between the model-derived metric of insulin resistance (ρ = 0.67, p 
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2024.109362