MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals

MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four...

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Veröffentlicht in:	Retrovirology 2008-12, Vol.5 (1), p.118-118, Article 118
Hauptverfasser:	Houzet, Laurent, Yeung, Man Lung, de Lame, Valery, Desai, Dhara, Smith, Stephen M, Jeang, Kuan-Teh
Format:	Artikel
Sprache:	eng
Schlagworte:	Cohort Studies Gene expression Gene Expression Regulation Genetic aspects HIV (Viruses) HIV Infections - blood HIV Infections - immunology HIV Seropositivity HIV-1 - immunology Humans Leukocytes, Mononuclear - metabolism MicroRNAs - blood MicroRNAs - metabolism Physiological aspects RNA T-Lymphocytes - metabolism
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Zusammenfassung:	MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes.
ISSN:	1742-4690 1742-4690
DOI:	10.1186/1742-4690-5-118