"Clicking" an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability

A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via "click" chemistry, and found to retain the parent peptide's activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant...

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Veröffentlicht in:	International journal of molecular sciences 2020-08, Vol.21 (17), p.6174
Hauptverfasser:	Gomes, Ana, Bessa, Lucinda J, Correia, Patrícia, Fernandes, Iva, Ferraz, Ricardo, Gameiro, Paula, Teixeira, Cátia, Gomes, Paula
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry antibacterial antibiofilm Antibiotics Antiinfectives and antibacterials Antimicrobial agents Antimicrobial peptides Azides - chemistry Bacteria Biofilms Biofilms - drug effects Biofilms - growth & development Cell Line Clinical isolates Communication Cycloaddition Reaction - methods Drug Resistance, Multiple, Bacterial - drug effects Enzymes Gram-negative bacteria Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - growth & development Gram-positive bacteria Humans Investigations ionic liquid Ionic liquids Ionic Liquids - chemistry Ionic Liquids - pharmacology Ions Klebsiella Microbial Sensitivity Tests Molecular Structure Multidrug resistance Multidrug resistant organisms NMR Nuclear magnetic resonance peptide Peptides Pore Forming Cytotoxic Proteins - chemistry Pore Forming Cytotoxic Proteins - pharmacology skin infections Stability Tyrosinase Wound healing
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Beschreibung
Zusammenfassung:	A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via "click" chemistry, and found to retain the parent peptide's activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of , while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms21176174