In vitro evaluation of erythromycin in chloroquine resistant brazilian P. falciparum freshly isolates: modulating effect and antimalarial activity evidence

In vitro evaluation of erythromycin in chloroquine resistant brazilian P. falciparum freshly isolates: modulating effect and antimalarial activity evidence

Erythromycin, a reversal agent in multidrug-resistant cancer, was assayed in chloroquine resistance modulation. The in vitro microtechnique for drug susceptibility was employed using two freshly isolates of Plasmodium falciparum from North of Brazil. The antimalarial effect of the drug was confirmed...

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Veröffentlicht in:Revista do Instituto de Medicina Tropical de São Paulo 1999-07, Vol.41 (4), p.249-253
Hauptverfasser: Menezes, C M, Kirchgatter, K, Di Santi, S M, Savalli, C, Monteiro, F G, Paula, G A, Ferreira, E I
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antimalarial activity
Antimalarials - pharmacology
Brazil
Chloroquine - pharmacology
Chloroquine P. falciparum resistance
Drug Resistance, Multiple
Erythromycin
Erythromycin - pharmacology
Erythromycin - therapeutic use
Female
Humans
Malaria, Falciparum - drug therapy
Male
Modulating effect
Plasmodium falciparum - drug effects
Plasmodium falciparum - isolation & purification
TROPICAL MEDICINE
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Zusammenfassung:Erythromycin, a reversal agent in multidrug-resistant cancer, was assayed in chloroquine resistance modulation. The in vitro microtechnique for drug susceptibility was employed using two freshly isolates of Plasmodium falciparum from North of Brazil. The antimalarial effect of the drug was confirmed, with an IC50 estimates near the usual antimicrobial therapy concentration, and a significant statistical modulating action was observed for one isolate.
ISSN:0036-4665
1678-9946
0036-4665
1678-9946
DOI:10.1590/S0036-46651999000400009