Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been demonstrated to be able to activate complement, making patients with deficiency in negative complement regulation, such as paroxysmal nocturnal hemoglobinuria (PNH), part...

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Veröffentlicht in:Case reports in hematology 2021-07, Vol.2021, p.1-6
Hauptverfasser: Otieno, Steve Biko, Altahan, Alaa, Kaweeta, Fnu, Karri, Saradasri, Alnoor, Fnu, Johnson, Robert
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Sprache:eng
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Zusammenfassung:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been demonstrated to be able to activate complement, making patients with deficiency in negative complement regulation, such as paroxysmal nocturnal hemoglobinuria (PNH), particularly vulnerable to complement-mediated cell damage. We report a case of a patient who presented with fatigue, facial swelling, and upper respiratory infection (URI) symptoms and was found to have COVID-19 with laboratory tests showing severe hemolysis and pancytopenia secondary to PNH.
ISSN:2090-6560
2090-6579
DOI:10.1155/2021/6619177