Divalent magnesium restores cytoskeletal storage lesions in cold-stored platelet concentrates

Divalent magnesium restores cytoskeletal storage lesions in cold-stored platelet concentrates

Cold storage of platelet concentrates (PC) has become attractive due to the reduced risk of bacterial proliferation, but in vivo circulation time of cold-stored platelets is reduced. Ca 2+ release from storage organelles and higher activity of Ca 2+ pumps at temperatures 

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Scientific reports 2022-04, Vol.12 (1), p.6229-6229, Article 6229
Hauptverfasser: Aurich, Konstanze, Wesche, Jan, Ulbricht, Martin, Otto, Oliver, Greinacher, Andreas, Palankar, Raghavendra
Format: Artikel
Sprache:eng
Schlagworte:
692/308
692/308/575
Biomechanics
Blood Platelets
Blood Preservation - methods
Calcium
Cold
Cold shock
Cryopreservation
Cytometry
Cytoskeleton
Deformability
Hemostasis
Humanities and Social Sciences
Immunofluorescence
Lesions
Magnesium
Magnesium - pharmacology
Mechanical properties
multidisciplinary
Organelles
Platelet Aggregation
Risk reduction
Science
Science (multidisciplinary)
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Cold storage of platelet concentrates (PC) has become attractive due to the reduced risk of bacterial proliferation, but in vivo circulation time of cold-stored platelets is reduced. Ca 2+ release from storage organelles and higher activity of Ca 2+ pumps at temperatures 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-10231-x