Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion

Objective: To investigate the clinicopathological correlation of parapapillary atrophy. Materials and Methods: The study included 16 eyes of rhesus monkeys (Macaca mulatta) - 4 eyes with experimental glaucoma, 11 eyes after experimental temporary occlusion of the central retinal artery, and 1 normal...

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Veröffentlicht in:	Indian journal of ophthalmology 2014-02, Vol.62 (2), p.219-223
Hauptverfasser:	Jonas, Jost, Hayreh, Sohan, Tao, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	A-scan Accommodation Acoustic features Amblyopia Animals Atrophy B-scan Bacterial BARC I-125 Ocu-Prosta seeds Blindness cataract Cataract surgery choroidal mass choroidal melanoma ciliary body melanoma citicoline Colour perception complications Congenital cataract Congenital glaucoma Contracted socket Contrast sensitivity function Corneal endothelium dermis fat graft Descemet′s stripping endothelial keratoplasty developmental cataract disability Disease Models, Animal Disease Progression donor dislocation education Endophthalmitis endothelial cell loss Episcleral plaque brachytherapy Exotropic Duane retraction syndrome explantation extracellular enzymes eye lens Follow-Up Studies function peak fungal Glaucoma glaucoma experimental Glaucoma, Open-Angle - pathology Glucose gonioscopy graft failure human corneal endothelial precursor cells in vitro anticataract in vitro expansion informed consent intraocular lens keratitis Lagophthalmos learning disabilities lens Low vision care Macaca mulatta Macular degeneration management Moringa oliefera multimedia multiple disabilities and visual impairment multiple sclerosis Ophthalmoscopy Optic atrophy Original outcome parapapillary atrophy patching periosteal fixation Photomicrography porous orbital implant postoperative presbyopia reading performance reconstruction recurrent Retcam Retina retinal angioma Retinal Artery Occlusion - pathology Retinal Pigment Epithelium - pathology retinoblastoma risk factors rural health school children silicone sling spatial frequency sphere forming assay stereo acuity strabismus surgery Studies supraciliary segment implants temporalis muscle testability thermo-reversible gelation polymer toxins transportation treatment of cataract ultrasound biomicroscopy vasoproliferative tumor vertical rectus transposition vision function visual acuity
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Zusammenfassung:	Objective: To investigate the clinicopathological correlation of parapapillary atrophy. Materials and Methods: The study included 16 eyes of rhesus monkeys (Macaca mulatta) - 4 eyes with experimental glaucoma, 11 eyes after experimental temporary occlusion of the central retinal artery, and 1 normal eye. On histological sections, we measured zones with different histological characteristics.On fundus photographs, alpha zone and beta zone of parapapillary atrophy were measured and correlated with the histological data. Results: The size of the clinical alpha zone of parapapillary atrophy was significantly correlated with the size of the histological region with irregularities of the retinal pigment epithelium (P = 0.05; correlation coefficient r = 0.49) and with the size of the histological region with a decreased density of retinal photoreceptors (P = 0.01; r = 0.60). The size of clinical beta zone of parapapillary atrophy significantly correlated with the size of the histological region with complete loss of the retinal pigment epithelium (P
ISSN:	0301-4738 1998-3689
DOI:	10.4103/0301-4738.111216