Letter to the Editor: An Updated Overview of Low Back Pain Management

The PACE trial (n=1,652) compared paracetamol to placebo in people with acute low back pain and found that paracetamol had no effect on pain, disability, function, global symptom change, sleep quality, or quality of life [2]. The Cochrane review published in 2016 (two trials, 1,785 patients) reported that here is high-quality evidence that paracetamol (compared to placebo) has no effect on quality of life, function, global impression of recovery, and sleep quality [4]. [...]the efficacy of paracetamol for chronic low back pain is uncertain.