Detection of a new reaction by-product in BDDE cross-linked autoclaved hyaluronic acid hydrogels by LC-MS analysis

Hyaluronic acid (HA), a naturally occurring polysaccharide, is used in the production of dermal fillers for esthetic purposes. As it has a few days of half-life in human tissues, HA-based dermal filler is chemically modified to increase its lifetime in the body. The most common modification used in...

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Veröffentlicht in:	Medical devices (Auckland, N.Z.) N.Z.), 2018-01, Vol.11, p.367-376
Hauptverfasser:	Fidalgo, Javier, Deglesne, Pierre-Antoine, Arroyo, Rodrigo, Sepúlveda, Lilian, Ranneva, Evgeniya, Deprez, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes BDDE BDDE byproduct Butanediol Chromatography Cross-linked hyaluronic acid Glycols (Class of compounds) HA dermal fillers Hyaluronic acid Hydrogels LC-MS analysis Liquid chromatography Mass spectrometry NMR Nuclear magnetic resonance Original Research Polysaccharides Propylene Spectroscopy
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Beschreibung
Zusammenfassung:	Hyaluronic acid (HA), a naturally occurring polysaccharide, is used in the production of dermal fillers for esthetic purposes. As it has a few days of half-life in human tissues, HA-based dermal filler is chemically modified to increase its lifetime in the body. The most common modification used in commercial HA-based filler is the cross-linking of HA chains using 1,4-butanediol diglycidyl ether (BDDE) as cross-linking agent. Residual, or unreacted, BDDE is considered nontoxic when it is
ISSN:	1179-1470 1179-1470
DOI:	10.2147/MDER.S166999