Increased risk of vascular complications in patients with type 2 diabetes and fatty liver disease

The prevalence of steatotic liver disease (SLD) in patients with type 2 diabetes (T2DM) exceeds 50%. This study aimed to investigate the clinical characteristics of SLD and liver fibrosis in Chinese patients with T2DM. Inpatients from 2021 to 2023 were included in the study. Fatty liver index (FLI)...

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Veröffentlicht in:	BMC endocrine disorders 2024-11, Vol.24 (1), p.235-8, Article 235
Hauptverfasser:	Sun, Weixia, Liu, Dechen, Yang, Ting, Zhou, Ziwei, Li, Dan, Zhao, Zhuoxiao, Zhang, Xuan, Wang, Liyun, Li, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Blood levels Blood pressure Blood sugar Body mass index Cardiovascular disease China - epidemiology Cholesterol Complications and side effects Coronary artery disease Coronary heart disease Creatinine Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology Diabetic nephropathies Diabetic nephropathy Diseases Enzymes Fatty liver Fatty Liver - complications Fatty Liver - epidemiology Fatty Liver - etiology Female Fibrosis Follow-Up Studies Foot diseases Glucose Glycosylated hemoglobin Heart diseases Hemoglobin Humans Insulin resistance Liver cirrhosis Liver Cirrhosis - complications Liver Cirrhosis - epidemiology Liver Cirrhosis - pathology Liver diseases Liver fibrosis Liver steatosis Male Medical colleges Metabolism Microvasculature Middle Aged Mortality Nephropathy Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - epidemiology Non-alcoholic Fatty Liver Disease - pathology Peptides Prevalence Prognosis Risk Factors Statistical analysis Steatosis Stroke (Disease) Triglycerides Type 2 diabetes Veins & arteries
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Zusammenfassung:	The prevalence of steatotic liver disease (SLD) in patients with type 2 diabetes (T2DM) exceeds 50%. This study aimed to investigate the clinical characteristics of SLD and liver fibrosis in Chinese patients with T2DM. Inpatients from 2021 to 2023 were included in the study. Fatty liver index (FLI) and fibrosis-4 (FIB-4) were calculated to assess hepatic steatosis and fibrosis respectively. Statistical analysis was completed by SPSS v25 and GraphPad Prism v8.0.1. Of the 1466 participants, about one-third of the patients in T2DM-SLD group were diagnosed with liver fibrosis (LF), and the percentage of patients over 50 years old was 85.9%. Patients with SLD had higher levels of BMI, blood pressure, liver enzymes, fasting blood glucose (FBG), HbA1c, C-peptide, total cholesterol (TC) and triglyceride (TG) (P
ISSN:	1472-6823 1472-6823
DOI:	10.1186/s12902-024-01766-3