Early Aberrant Angiogenesis Due to Elastic Fiber Fragmentation in Aortic Valve Disease

Early Aberrant Angiogenesis Due to Elastic Fiber Fragmentation in Aortic Valve Disease

Elastic fiber fragmentation (EFF) is a hallmark of aortic valve disease (AVD), and neovascularization has been identified as a late finding related to inflammation. We sought to characterize the relationship between early EFF and aberrant angiogenesis. To examine disease progression, regional anatom...

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Veröffentlicht in:Journal of cardiovascular development and disease 2021-06, Vol.8 (7), p.75
Hauptverfasser: Hinton, Robert B., Juraszek, Amy L., Opoka, Amy M., Landis, Benjamin J., Smith, J. Michael, Mecham, Robert P., Bove, Kevin E.
Format: Artikel
Sprache:eng
Schlagworte:
Age
Angiogenesis
aortic root
Atherosclerosis
Calcification
Cardiovascular disease
elastic fiber
Extracellular matrix
Heart
heart valves
Hospitals
Inflammation
Pathogenesis
Pediatrics
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Zusammenfassung:Elastic fiber fragmentation (EFF) is a hallmark of aortic valve disease (AVD), and neovascularization has been identified as a late finding related to inflammation. We sought to characterize the relationship between early EFF and aberrant angiogenesis. To examine disease progression, regional anatomy and pathology of aortic valve tissue were assessed using histochemistry, immunohistochemistry, and electron microscopy from early-onset (
ISSN:2308-3425
2308-3425
DOI:10.3390/jcdd8070075