PPAR Gamma and Angiogenesis: Endothelial Cells Perspective

We summarize the current knowledge concerning PPARγ function in angiogenesis. We discuss the mechanisms of action for PPARγ and its role in vasculature development and homeostasis, focusing on endothelial cells, endothelial progenitor cells, and bone marrow-derived proangiogenic cells.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of Diabetes Research 2016-01, Vol.2016 (2016), p.1-11
Hauptverfasser:	Kotlinowski, Jerzy, Józkowicz, Alicja
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Angiogenesis Animals Bone marrow Bone Marrow Cells - cytology Cardiovascular system Cell Movement Cytokines Embryonic development Embryos Endothelial Cells - cytology Endothelium Gene expression Homeostasis Humans Ischemia Ligands Mice Mice, Knockout Neovascularization Neovascularization, Pathologic Nitric oxide Physiology PPAR gamma - metabolism PPAR gamma - physiology Review Stem Cells - cytology Transcription Factors - metabolism Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Wound healing
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Beschreibung
Zusammenfassung:	We summarize the current knowledge concerning PPARγ function in angiogenesis. We discuss the mechanisms of action for PPARγ and its role in vasculature development and homeostasis, focusing on endothelial cells, endothelial progenitor cells, and bone marrow-derived proangiogenic cells.
ISSN:	2314-6745 2314-6753
DOI:	10.1155/2016/8492353