Syndecan 4-c-ros oncogene 1 fusion as a mechanism of acquired resistance in epidermal growth factor receptor mutant lung adenocarcinoma

In the study, we did not detect additional resistance mechanisms to first- or second-generation EGFR-TKIs, such as an EGFR (Thr790Met) T790M mutation, human epidermal growth factor receptor-2 amplification, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha mutation, mesenchymal-epithelial transition amplification, and small cell transformation. [...]this report indicates that the SDC4-ROS1 rearrangement may function as a possible mechanism of acquired resistance to EGFR-TKIs in EGFR-mutant lung adenocarcinomas (LADCs). [...]52 different ROS1 rearrangements have been identified in NSCLC, including cluster of differentiation74-syndecan 4-ROS1 (CD74-ROS1), solute carrier family 34 member 2-syndecan 4-ROS1, ezrin-syndecan 4-ROS1, SDC4-ROS1, tropomyosin 3-ROS1, golgi associated PDZ and coiled-coil motif containing-ROS1 (GOPC-ROS1), leucine rich repeats and immunoglobulin like domains 3-syndecan 4-ROS1, Homo sapiens fidgetin like 1-syndecan 4-ROS1, trafficking from ER to golgi regulator-syndecan 4-ROS1, LIM domain and actin binding 1-syndecan 4-ROS1, Moesin-ROS1, clathrin heavy chain-syndecan 4-ROS1, TPD52 like 1-syndecan 4-ROS1, centrosomal protein 72-syndecan 4-ROS1, KDEL endoplasmic reticulum protein retention receptor 2-syndecan 4-ROS1, RNA binding region containing 3-syndecan 4-ROS1, zinc finger CCHC-type containing 8-syndecan 4-ROS1, myosin heavy chain 9-syndecan 4-ROS1, G protein-coupled receptor class C group 6 member A-syndecan 4-ROS1, regulatory factor X6-syndecan 4-ROS1, aquaporin 4-syndecan 4-ROS1, adhesion G protein-coupled receptor G6-syndecan 4-ROS1, tripartite motif containing 33-syndecan 4-ROS1, coiled-coil domain containing 6-ROS1, syndecan 4-ROS1-family with sequence similarity 135 member B, solute carrier family 6 member 17-syndecan 4-ROS1, ROS1-adhesion G protein-coupled receptor G6, myosin VA-syndecan 4-ROS1, myosin VC-syndecan 4-ROS1, catenin delta 2syndecan 4-ROS1, opioid receptor Mu 1-syndecan 4-ROS1, serine and arginine rich splicing factor 6-syndecan 4-ROS1, UncharacterizedLOC101927919-syndecan4-ROS1, breast cancer-associated transcript 107-syndecan 4-ROS1, osteoblast specific factor-ROS1, muscle RAS oncogene homolog-ROS1, adhesion G protein-coupled receptor V1-syndecan 4-ROS1, pumilio RNA binding family member 1-syndecan 4-ROS1, BTB domain containing 9-syndecan 4-ROS1, X-prolyl aminopeptidase 1-syndecan 4-ROS1, WNK lysine deficient protein kinase 1-syndecan 4-ROS1, PPFIA binding protein 1-syndecan 4-ROS1, PWWP dom