Role of emmprin in endometrial cancer

Extracellular matrix metalloproteinase inducer (Emmprin/CD147) is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. Enriched on the surface of many tumor cells, emmprin promotes tumor growth, invasion, metastasis and angiogenesis. We evaluated the clinical importance of em...

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Veröffentlicht in:	BMC cancer 2012-05, Vol.12 (1), p.191-191, Article 191
Hauptverfasser:	Nakamura, Keiichiro, Kodama, Junichi, Hongo, Atsushi, Hiramatsu, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Basigin - analysis Basigin - biosynthesis Biomarkers, Tumor - analysis Blotting, Western Cancer Carcinoma - metabolism Carcinoma - mortality Carcinoma - pathology Cell Line, Tumor Comparative analysis Development and progression Disease-Free Survival Emmprin Endometrial cancer Endometrial Neoplasms - metabolism Endometrial Neoplasms - mortality Endometrial Neoplasms - pathology Epidermal growth factor Epithelial-mesenchymal transition Female Glycoproteins Growth factors Health aspects Humans Immunohistochemistry Insulin-like growth factors Kaplan-Meier Estimate Membrane proteins Metastasis Middle Aged Neoplasm Staging Physiological aspects Potential therapeutic target Predictor of favorable prognosis Proteins Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering Transfection Vascular endothelial growth factor
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Zusammenfassung:	Extracellular matrix metalloproteinase inducer (Emmprin/CD147) is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. Enriched on the surface of many tumor cells, emmprin promotes tumor growth, invasion, metastasis and angiogenesis. We evaluated the clinical importance of emmprin and investigated its role in endometrial cancer. Emmprin expression was examined in uterine normal endometrium, endometrial hyperplasia and cancer specimens by immunohistochemistry. In addition, the biological functions and inhibitory effects of an emmprin knockdown were investigated in HEC-50B and KLE endometrial cancer cell lines. The levels of emmprin expression were significantly increased in the endometrial cancer specimens compared with the normal endometrium and endometrial hyperplasia specimens (p
ISSN:	1471-2407 1471-2407
DOI:	10.1186/1471-2407-12-191