Clozapine Serum Concentrations Are Disrupted by SARS-CoV-2 Vaccinations

Clozapine Serum Concentrations Are Disrupted by SARS-CoV-2 Vaccinations

This paper reports the case of a 27-year-old man with paranoid schizophrenia who was finally stabilized on clozapine medication. After vaccination against severe acute respiratory syndrome coronavirus 2, serum levels of clozapine increased. It is well established that immune responses can trigger cy...

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Veröffentlicht in:Case reports in psychiatry 2023-11, Vol.2023, p.9914879-4
Hauptverfasser: Kersting, Xenia A. K., Momtahen, Nicoletta, Lieb, Klaus
Format: Artikel
Sprache:eng
Schlagworte:
Antipsychotics
Blood
Case Report
Clozapine
Coronaviruses
COVID-19 vaccines
Cytokines
Drug dosages
Health aspects
Immune response
Infections
Influenza
Leukocytes
Mental disorders
Mental illness
Metabolism
Metabolites
mRNA vaccines
Neutrophils
Pandemics
Patients
Physiological aspects
Schizophrenia
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Therapeutic drug monitoring
Vaccination
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Zusammenfassung:This paper reports the case of a 27-year-old man with paranoid schizophrenia who was finally stabilized on clozapine medication. After vaccination against severe acute respiratory syndrome coronavirus 2, serum levels of clozapine increased. It is well established that immune responses can trigger cytokine cascades affecting drug metabolism, which, in the case of clozapine treatment, can lead to severe intoxication.
ISSN:2090-682X
2090-6838
DOI:10.1155/2023/9914879