Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease

The relationship between baseline serum albumin level and long-term prognosis of patients with nonalcoholic fatty liver disease (NAFLD) remains unknown. This is a sub-analysis of the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) study. The main outcomes were: death or orthotopic liver t...

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Veröffentlicht in:	Nutrients 2023-04, Vol.15 (9), p.2014
Hauptverfasser:	Takahashi, Hirokazu, Kawanaka, Miwa, Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Tsutsumi, Tsubasa, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, Arakaki, Shingo, Kawaguchi, Takumi, Noritake, Hidenao, Ono, Masafumi, Masaki, Tsutomu, Yasuda, Satoshi, Tomita, Eiichi, Yoneda, Masato, Tokushige, Akihiro, Kamada, Yoshihiro, Ueda, Shinichiro, Aishima, Shinichi, Sumida, Yoshio, Nakajima, Atsushi, Okanoue, Takeshi, Japan Study Group Of Nonalcoholic Fatty Liver Disease Jsg-Nafld
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Albumin Algorithms Asian Biopsy Cirrhosis Cohort analysis Comparative analysis Death Fatty liver Female Hepatocellular carcinoma Humans Liver Liver cancer Liver cirrhosis Liver Cirrhosis - etiology Liver diseases Liver transplantation Male Medical research Medicine, Experimental Middle Aged Mortality Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology nonalcoholic steatohepatitis Prognosis Serum albumin Serum Albumin, Human - analysis Serum Albumin, Human - metabolism Statistical analysis Transplantation
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Zusammenfassung:	The relationship between baseline serum albumin level and long-term prognosis of patients with nonalcoholic fatty liver disease (NAFLD) remains unknown. This is a sub-analysis of the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) study. The main outcomes were: death or orthotopic liver transplantation (OLT), liver-related death, and liver-related events (hepatocellular carcinoma [HCC], decompensated cirrhosis, and gastroesophageal varices/bleeding). 1383 Japanese patients with biopsy-confirmed NAFLD were analyzed. They were divided into 3 groups based on serum albumin: high (>4.0 g/dL), intermediate (3.5-4.0 g/dL), and low (
ISSN:	2072-6643 2072-6643
DOI:	10.3390/nu15092014