A novel method for assessment of airway opening pressure without the need for low-flow insufflation

Airway opening pressure (AOP) detection and measurement are essential for assessing respiratory mechanics and adapting ventilation. We propose a novel approach for AOP assessment during volume assist control ventilation at a usual constant-flow rate of 60 L/min. To validate the conductive pressure (P ) method, which compare the P -defined on the airway pressure waveform as the difference between the airway pressure level at which an abrupt change in slope occurs at the beginning of insufflation and PEEP-to resistive pressure for AOP detection and measurement, and to compare its respiratory and hemodynamic tolerance to the standard low-flow insufflation method. The proof-of-concept of the P method was assessed on mechanical (lung simulator) and physiological (cadavers) bench models. Its diagnostic performance was evaluated in 213 patients, using the standard low-flow insufflation method as a reference. In 45 patients, the respiratory and hemodynamic tolerance of the P method was compared with the standard low-flow method. Bench assessments validated the P method proof-of-concept. Sensitivity and specificity of the P method for AOP detection were 93% and 91%, respectively. AOP obtained by P and standard low-flow methods strongly correlated (r = 0.84, p