Human cellular restriction factors that target HIV-1 replication

Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite mot...

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Veröffentlicht in:	BMC medicine 2009-09, Vol.7 (1), p.48-48, Article 48
Hauptverfasser:	Strebel, Klaus, Luban, Jeremy, Jeang, Kuan-Teh
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Antigens, CD - physiology APOBEC-3G Deaminase Carrier Proteins - physiology Cyclophilin A - physiology Cytidine Deaminase - physiology Genetic aspects GPI-Linked Proteins HIV HIV (Viruses) HIV Infections - immunology HIV Infections - virology HIV-1 - immunology Human immunodeficiency virus Humans Immunity, Innate Kinases Membrane Glycoproteins - physiology MicroRNAs - physiology Minireview Proteins Restriction-modification system Virus Replication - immunology Viruses
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Beschreibung
Zusammenfassung:	Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5alpha), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.
ISSN:	1741-7015 1741-7015
DOI:	10.1186/1741-7015-7-48