Correlation between loss of Smad4 and clinical parameters of non-small cell lung cancer: an observational cohort study

SMAD4 has been found to be inactivated to varying degrees in many types of cancer; the purpose of this study was to investigate the correlation between SMAD4 expression in non-small cell lung cancer (NSCLC) and clinical pathological parameters. The serum concentration of SMAD4 was measured by enzyme...

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Veröffentlicht in:	BMC pulmonary medicine 2021-04, Vol.21 (1), p.111-111, Article 111
Hauptverfasser:	Guo, Xiangjun, Li, Mengmeng, Wang, Xin, Pan, Yun, Li, Jiashu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Biotechnology industry Blood tests Cancer Cancer therapies Cell differentiation Cohort analysis Diagnosis Electrolytes Enzyme-linked immunosorbent assay Enzymes Evaluation Gene expression Genetic aspects Health aspects Immunohistochemistry Lung cancer Lung cancer, Non-small cell Lung diseases Lymph nodes Metastases Non-small cell lung cancer Non-small cell lung carcinoma NSCLC Observational studies Oncology, Experimental Pulmonology Smad proteins Smad4 Smad4 protein Small cell lung carcinoma Statistical analysis Tuberculosis Tumors Ultrasonic imaging
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Zusammenfassung:	SMAD4 has been found to be inactivated to varying degrees in many types of cancer; the purpose of this study was to investigate the correlation between SMAD4 expression in non-small cell lung cancer (NSCLC) and clinical pathological parameters. The serum concentration of SMAD4 was measured by enzyme-linked immunosorbent assay and its histological expression was quantified by immunohistochemistry. The serum concentration of Smad4 in patients with NSCLC was lower than that in benign lung disease patients and healthy individuals (P
ISSN:	1471-2466 1471-2466
DOI:	10.1186/s12890-021-01480-z