Synthesis of 2,4-disubstituted quinazolines promoted by deep eutectic solvent

Synthesis of 2,4-disubstituted quinazolines promoted by deep eutectic solvent

An efficient deep eutectic solvent (DES) promoted reaction of 2-amino-5-chlorobenzophenone, aromatic aldehydes (benzoyl alcohols) and ammonium acetate leading to the formation of quinazolines with excellent yields is described. The use of expensive catalysts and organic solvents are avoided in this...

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Veröffentlicht in:Current research in green and sustainable chemistry 2021, Vol.4, p.100130, Article 100130
Hauptverfasser: Singh, Rajkumar Romeshkumar, Singh, Thokchom Prasanta, Devi, Thangjam Linda, Devi, Thokchom Jeeta, Singh, Okram Mukherjee
Format: Artikel
Sprache:eng
Schlagworte:
Benzyl alcohol
Biodegradable
Deep eutectic solvent
Quinazoline
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Zusammenfassung:An efficient deep eutectic solvent (DES) promoted reaction of 2-amino-5-chlorobenzophenone, aromatic aldehydes (benzoyl alcohols) and ammonium acetate leading to the formation of quinazolines with excellent yields is described. The use of expensive catalysts and organic solvents are avoided in this protocol with the use of DES, which is biodegradable and renewable. [Display omitted] •Synthesis of quinazolines using ChCl:Urea (deep eutectic solvent).
ISSN:2666-0865
2666-0865
DOI:10.1016/j.crgsc.2021.100130