Ziziphi Spinosae Semen Flavonoids alleviates liver oxidative damage induced by perfluorooctane sulfonate in mice
Objective To study the protective effect of Ziziphi Spinosae Semen Flavonoids (ZSSF) on liver oxidative damage induced by perfluorooctane sulfonate (PFOS) in mice. Methods Mice were divided into blank control group, model group, positive control group (vitamin C group) and high, medium and low dose...
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Veröffentlicht in: | Ji chu yi xue yu lin chuang = Jichu yixue yu linchuang = Basic medical sciences and clinics 2021-02, Vol.41 (2), p.184-188 |
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Format: | Artikel |
Sprache: | chi |
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Zusammenfassung: | Objective To study the protective effect of Ziziphi Spinosae Semen Flavonoids (ZSSF) on liver oxidative damage induced by perfluorooctane sulfonate (PFOS) in mice. Methods Mice were divided into blank control group, model group, positive control group (vitamin C group) and high, medium and low dose ZSSF group by random number table method, with 10 mice in each group. At the same time, PFOS (10 mg/kg) was molded and administered continuously for 30 days.After 6 h after the last delivery, eyeball blood in mice, the liver to join 9 times the volume of 0.9% sodium chloride solution in homogenate is made from 10% of the tissue of slurry, according to the kit instruction alanine transaminase (ALT) in serum and aspirate aminotransferase (AST), superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione peroxidase (gsh-px) and catalase (CAT) and total antioxidant capacity (T -AOC) level; The expression of Nrf2 and HO-1 mrna in liver tissues was detected, and real-time fluorescent quantitative PCR(RT-qPCR) was a |
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ISSN: | 1001-6325 |