A Novel Heterocyclic System Based on Natural Epoxyalantolactone

Natural sesquiterpene lactones which contain an exocyclic methylene group in the β-position of the lactone ring react readily with N-nucleophiles. When studying the reaction of the natural epoxyalantolactone with the primary amines we demonstrate the formation of a new heterocyclic system—the hydrog...

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Veröffentlicht in:	Frontiers in chemistry 2019-10, Vol.7, p.655-655
Hauptverfasser:	Klochkov, Sergey G., Pukhov, Sergey A., Afanasieva, Svetlana V., Neganova, Margarita E., Ananiev, Ivan V., Avila-Rodriguez, Marco, Tarasov, Vadim V., Aliev, Gjumrakch
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry epoxyalantolactone Michael reaction new heterocyclic system sesquiterpene lactones synthesis
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Beschreibung
Zusammenfassung:	Natural sesquiterpene lactones which contain an exocyclic methylene group in the β-position of the lactone ring react readily with N-nucleophiles. When studying the reaction of the natural epoxyalantolactone with the primary amines we demonstrate the formation of a new heterocyclic system—the hydrogenated benzo[g]furo[4,3,2-cd]indol-3(1H)-one. Spectral data on the characteristics of the synthesized compounds are presented. The data on the reaction mechanisms and its applicability for the preparation are discussed.
ISSN:	2296-2646 2296-2646
DOI:	10.3389/fchem.2019.00655