The Protective Effect of a Newly Developed Molecular Chaperone– Inducer Against Mouse Ischemic Acute Kidney Injury

Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on rena...

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Veröffentlicht in:	Journal of Pharmacological Sciences 2009, Vol.109(2), pp.311-314
Hauptverfasser:	Prachasilchai, Worapat, Sonoda, Hiroko, Yokota-Ikeda, Naoko, Ito, Katsuaki, Kudo, Takashi, Imaizumi, Kazunori, Ikeda, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals endoplasmic reticulum (ER) stress Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Ischemia - drug therapy Kidney - injuries Male Mice Mice, Inbred Strains Molecular Chaperones - genetics Molecular Chaperones - metabolism renal ischemia-reperfusion injury Reperfusion Injury - prevention & control RNA, Messenger - metabolism Thiocyanates - therapeutic use Transcriptional Activation Tunicamycin - administration & dosage Tunicamycin - pharmacology unfolded protein response Up-Regulation
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Zusammenfassung:	Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Coadministration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury.
ISSN:	1347-8613 1347-8648
DOI:	10.1254/jphs.08272SC