Cavitation is the determining mechanism for the atomization of high-viscosity liquid

Piezoelectric atomization is becoming mainstream in the field of inhalation therapy due to its significant advantages. With the rapid development of high-viscosity gene therapy drugs, the demand for piezoelectric atomization devices is increasing. However, conventional piezoelectric atomizers with a single-dimensional energy supply are unable to provide the energy required to atomize high-viscosity liquids. To address this problem, our team has designed a flow tube internal cavitation atomizer (FTICA). This study focuses on dissecting the atomization mechanism of FTICA. In contrast to the widely supported capillary wave hypothesis, our study provides evidence in favor of the cavitation hypothesis, proving that cavitation is the key to atomizing high-viscosity liquids with FTICA. In order to prove that the cavitation is the key to atomizing in the structure of FTICA, the performance of atomization is experimented after changing the cavitation conditions by heating and stirring of the liquids. [Display omitted] •Cavitation is the determining factor for the atomization of high-viscosity liquids•Supporting the minority-endorsed cavitation hypothesis•FTICA is suitable for the atomization of biological proteins•The atomization of FTICA is a physical change Engineering; Mechanical engineering; Physical chemistry; Physic.