Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase

Little is known about the impact of pretreatment drug resistance (PDR) on the efficacy of second generation integrase inhibitors. We sequenced pretreatment plasma specimens from the ADVANCE trial (NCT03122262). Our primary outcome was 96-week virologic success, defined as a sustained viral load

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Veröffentlicht in:	Nature communications 2020-12, Vol.11 (1), p.5922-10, Article 5922
Hauptverfasser:	Siedner, Mark J., Moorhouse, Michelle A., Simmons, Bryony, de Oliveira, Tulio, Lessells, Richard, Giandhari, Jennifer, Kemp, Stephen A., Chimukangara, Benjamin, Akpomiemie, Godspower, Serenata, Celicia M., Venter, Willem D. F., Hill, Andrew, Gupta, Ravindra K.
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/88 631/326/596/1787 692/4017 Adult Africa South of the Sahara Anti-HIV Agents - therapeutic use Cohort Studies Drug resistance Drug Resistance, Viral Female HIV HIV Infections - drug therapy HIV Infections - virology HIV Integrase - genetics HIV Integrase - metabolism HIV Integrase Inhibitors - administration & dosage HIV Reverse Transcriptase - genetics HIV Reverse Transcriptase - metabolism HIV-1 - drug effects HIV-1 - enzymology HIV-1 - genetics Human immunodeficiency virus Humanities and Social Sciences Humans Impact resistance Inhibitors Integrase Male multidisciplinary Mutation Next-generation sequencing Non-nucleoside reverse transcriptase inhibitors Pretreatment RNA-directed DNA polymerase Science Science (multidisciplinary) Viral Load - drug effects
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Beschreibung
Zusammenfassung:	Little is known about the impact of pretreatment drug resistance (PDR) on the efficacy of second generation integrase inhibitors. We sequenced pretreatment plasma specimens from the ADVANCE trial (NCT03122262). Our primary outcome was 96-week virologic success, defined as a sustained viral load
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-020-19801-x