Bedaquiline as Treatment for Disseminated Nontuberculous Mycobacteria Infection in 2 Patients Co-Infected with HIV

Nontuberculous mycobacteria can cause disseminated infections in immunocompromised patients and are challenging to treat because of antimicrobial resistance and adverse effects of prolonged multidrug treatment. We report successful treatment with bedaquiline, a novel antimycobacterial drug, as part...

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Veröffentlicht in:	Emerging infectious diseases 2021-03, Vol.27 (3), p.944-948
Hauptverfasser:	Gil, Eliza, Sweeney, Nicola, Barrett, Veronica, Morris-Jones, Stephen, Miller, Robert F, Johnston, Victoria J, Brown, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen antibacterial drugs antiinfective drugs Antimicrobial agents antitubercular drugs bedaquiline Bedaquiline as Treatment for Disseminated Nontuberculous Case studies Disease Dispatch Drug resistance Drug therapy HIV HIV patients Human immunodeficiency virus Infection in 2 Patients Co-Infected with HIV Infections Laboratories Lymphatic system Mycobacteriaceae Mycobacterial infections Mycobacterium Patients Tuberculosis
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Beschreibung
Zusammenfassung:	Nontuberculous mycobacteria can cause disseminated infections in immunocompromised patients and are challenging to treat because of antimicrobial resistance and adverse effects of prolonged multidrug treatment. We report successful treatment with bedaquiline, a novel antimycobacterial drug, as part of combination therapy for 2 patients with disseminated nontuberculous mycobacteria co-infected with HIV.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2703.202359