Lewis Acid-Catalyzed Enantioselective Friedel–Crafts Alkylation of Pyrrole in Water

Lewis Acid-Catalyzed Enantioselective Friedel–Crafts Alkylation of Pyrrole in Water

Highly enantioselective Friedel–Crafts alkylation of pyrroles with 2-enoyl-pyridine N -oxides in water/chloroform (10:1) was developed under catalysis of Lewis acid. The Friedel–Crafts alkylation products can be obtained in high yields and excellent enantioselectivities. Moreover, several control ex...

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Veröffentlicht in:ACS omega 2020-06, Vol.5 (21), p.11962-11970
Hauptverfasser: Sun, Jianan, Gui, Yang, Huang, Yekai, Li, Jindong, Zha, Zhenggen, Yang, Yu, Wang, Zhiyong
Format: Artikel
Sprache:eng
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Zusammenfassung:Highly enantioselective Friedel–Crafts alkylation of pyrroles with 2-enoyl-pyridine N -oxides in water/chloroform (10:1) was developed under catalysis of Lewis acid. The Friedel–Crafts alkylation products can be obtained in high yields and excellent enantioselectivities. Moreover, several control experiments were carried out to study the reaction mechanism.
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.9b04115