Central lymph node metastasis is predictive of survival in advanced gastric cancer patients treated with D2 lymphadenectomy

The number of positive lymph nodes, which was defined as "N stage", is mostly used to predict the survival of D2-resected gastric cancer patients, not the location. A "central lymph node" (CnLN) was defined by Ikoma et al., included common hepatic, celiac and proximal splenic art...

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Veröffentlicht in:BMC gastroenterology 2021-01, Vol.21 (1), p.15-15, Article 15
Hauptverfasser: Lu, Huiwen, Zhao, Bochao, Huang, Rui, Sun, Yimeng, Zhu, Zirui, Xu, Huimian, Huang, Baojun
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Sprache:eng
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Zusammenfassung:The number of positive lymph nodes, which was defined as "N stage", is mostly used to predict the survival of D2-resected gastric cancer patients, not the location. A "central lymph node" (CnLN) was defined by Ikoma et al., included common hepatic, celiac and proximal splenic artery LNs. CnLNs located in the extraperigastric area are included in the D2 LN station for gastric cancer. We speculate that CnLNs can be regarded as a predictor of survival. Eligible advanced gastric cancer patients who underwent curative resection and D2 lymph node dissection between 2004 and 2012 at our institution were identified. The frequency of CnLN metastases and risk factors affecting DFS were examined. Survival differences were assessed by log-rank tests and Kaplan-Meier curves. The study identified 1178 patients who underwent curative surgery or D2 or more extensive lymphadenectomy. A total of 342 patients had been proven to have CnLN metastasis. Larger tumor size (P 
ISSN:1471-230X
1471-230X
DOI:10.1186/s12876-020-01578-4