Obesity Paradox of All-Cause Mortality in 4,133 Patients Treated with Coronary Revascularization

Objectives. The purpose of this study was to determine whether there is a dose-response relationship between body mass index (BMI) and all-cause mortality in patients after coronary revascularization. Methods. The MIMIC-III database (version 1.4) was used as the sample population. For variables with less than 10% of values missing, we used the mice package of R software for multiple imputations. Cox regression was used to determine the risk factors of all-cause mortality in patients. RCSs were used to observe the relationship between BMI and all-cause mortality. Additional subgroup and sensitivity analyses were also performed to explore whether the conclusion can be applied to specific groups. Results. Both univariate and multivariate Cox models indicated that the mortality risk was lower for overweight patients than for normal-weight patients (P