Accumulation of L-type bovine prions in peripheral nerve tissues

Accumulation of L-type bovine prions in peripheral nerve tissues

We recently reported the intraspecies transmission of L-type atypical bovine spongiform encephalopathy (BSE). To clarify the peripheral pathogenesis of L-type BSE, we studied prion distribution in nerve and lymphoid tissues obtained from experimentally challenged cattle. As with classical BSE prions...

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Veröffentlicht in:Emerging infectious diseases 2010-07, Vol.16 (7), p.1151-1154
Hauptverfasser: Iwamaru, Yoshifumi, Imamura, Morikazu, Matsuura, Yuichi, Masujin, Kentaro, Shimizu, Yoshihisa, Shu, Yujing, Kurachi, Megumi, Kasai, Kazuo, Murayama, Yuichi, Fukuda, Shigeo, Onoe, Sadao, Hagiwara, Ken'ichi, Yamakawa, Yoshio, Sata, Tetsutaro, Mohri, Shirou, Okada, Hiroyuki, Yokoyama, Takashi
Format: Artikel
Sprache:eng
Schlagworte:
Animals
atypical bovine spongiform encephalopathy
Cattle
Creutzfeldt-Jacob disease
Dispatch
distribution
Encephalopathy, Bovine Spongiform - etiology
L-type
nerve tissues
Peripheral Nerves - metabolism
Prions - metabolism
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Zusammenfassung:We recently reported the intraspecies transmission of L-type atypical bovine spongiform encephalopathy (BSE). To clarify the peripheral pathogenesis of L-type BSE, we studied prion distribution in nerve and lymphoid tissues obtained from experimentally challenged cattle. As with classical BSE prions, L-type BSE prions accumulated in central and peripheral nerve tissues.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1607.091882