AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia

AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia

Background. Recent data suggest that the renin-angiotensin system may be involved in triglyceride (TG) metabolism. We explored the effect of the common A1166C and C573T polymorphisms of the angiotensin II type 1 receptor (AT1R) gene on postprandial lipemia. Methods. Eighty-two subjects measured dayt...

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Veröffentlicht in:International Journal of Vascular Medicine 2012-01, Vol.2012 (2012), p.77-82
Hauptverfasser: Elte, J. W. F., Cabezas, Manuel Castro, Klop, Boudewijn, Carmena, R., Ascaso, J. F., Real, J. T., van den Berg, T. M., Rietveld, A. P., Chaves, J.
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Sprache:eng
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Clinical Study
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Zusammenfassung:Background. Recent data suggest that the renin-angiotensin system may be involved in triglyceride (TG) metabolism. We explored the effect of the common A1166C and C573T polymorphisms of the angiotensin II type 1 receptor (AT1R) gene on postprandial lipemia. Methods. Eighty-two subjects measured daytime capillary TG, and postprandial lipemia was estimated as incremental area under the TG curve. The C573T and A1166C polymorphisms of the AT1R gene were determined. Results. Postprandial lipemia was significantly higher in homozygous carriers of the 1166-C allele (9.39±8.36 mM*h/L) compared to homozygous carriers of the 1166-A allele (2.02±6.20 mM*h/L) (P
ISSN:2090-2824
2090-2832
DOI:10.1155/2012/271030