Long-term effects of the SLC2A9 G844A and SLC22A12 C246T variants on serum uric acid concentrations in children

We evaluated the effects of two single-nucleotide polymorphisms on UA concentrations in the first decade of life using repeated-measures data. We included all subjects who were followed-up at least once and for whom we had both UA and genotypic data (i.e., 375, 204, 307, and 363 patients aged 3, 5,...

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Veröffentlicht in:	BMC pediatrics 2018-09, Vol.18 (1), p.296-296, Article 296
Hauptverfasser:	Lee, Hye Ah, Park, Bo Hyun, Park, Eun Ae, Cho, Su Jin, Kim, Hae Soon, Park, Hyesook
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Blood pressure Children Children & youth Epidemiology Genes Genomes Genomics Hypertension Kidneys Longitudinal studies Longitudinal study Pediatric research Population Rheumatism Single nucleotide polymorphisms Urate transporter 1 Uric acid
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Zusammenfassung:	We evaluated the effects of two single-nucleotide polymorphisms on UA concentrations in the first decade of life using repeated-measures data. We included all subjects who were followed-up at least once and for whom we had both UA and genotypic data (i.e., 375, 204, 307, and 363 patients aged 3, 5, 7, and 9 years, respectively). All participated in the Ewha Birth and Growth Cohort study. We used a mixed model analysis to estimate the longitudinal association of serum UA concentration due to the rs3825017 (SLC22A12 c. 246C > T) and rs16890979 (SLC2A9 c. 844G > A) genotypes. Overall, the tracking coefficient of UA concentrations in children 3 to 9 years of age was 0.31, and was higher in boys than in girls (0.34 vs. 0.29, respectively). Regarding individual variance, serum UA concentrations decreased as age increased (β = - 0.07, p
ISSN:	1471-2431 1471-2431
DOI:	10.1186/s12887-018-1272-y