Longitudinal circulating tumour DNA dynamics predict failure patterns and efficacy of consolidation immunotherapy after chemoradiotherapy in locally advanced non‐small‐cell lung cancer

According to post-CRT ctDNA minus baseline ctDNA levels, the dynamic change pattern of longitudinal ctDNA included decreased (n = 54), stably undetectable (n = 30), and increased (n = 19; Figure 2H). In the clinical setting, for patients with solitary lesions of suspected metastasis,6 dynamic ctDNA testings may contribute to differential diagnosis between primary and metastatic diseases, as increased ctDNA indicates the hematogenous spread of tumour cells in the peripheral circulation7 3) Stably undetectable ctDNA predicts excellent outcomes irrespective of consolidation ICI, suggesting the potentially curable population with CRT.2 Cox regression analysis demonstrated consolidation ICI, post-CRT ctDNA, and dynamic ctDNA changes were significant variables in predicting PFS (Table S2 and Figure S1). [...]we compared the prediction effects and clinical decision-making benefits of single-time ctDNA detection with longitudinal ctDNA dynamics. Real-world safety and efficacy of consolidation durvalumab after chemoradiation therapy for stage iii non-small cell lung cancer: a systematic review and meta-analysis.