Delayed hypersensitivity reaction of hyaluronic acid filler (VCY-20)

Hyaluronic acid filler, a temporary injectable used for rejuvenating facial treatments, has gained significant popularity over the years due to its nonsurgical approach. While these procedures are generally safe, there are certain complications associated with their application. These complications can be categorized into early-, delayed-, and late-onset reactions. In this case report, we present a 55-year-old female who experienced a delayed hypersensitivity reaction following the application of hyaluronic acid filler, resulting in generalized facial edema.