Novel molecular insights and new therapeutic strategies in osteosarcoma

Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and poor overall prognosis mainly in children and adolescents. Identifying the molecular mechanisms and OS stem cells (OSCs) as new concepts involved in disease pathogenesis and progression may potentially lead to n...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer Cell International 2018-10, Vol.18 (1), p.158-158, Article 158
Hauptverfasser:	Otoukesh, Babak, Boddouhi, Bahram, Moghtadaei, Mehdi, Kaghazian, Peyman, Kaghazian, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescents Apoptosis Bone cancer Cancer therapies Cancer therapy Chemotherapy Children Drug resistance Drug therapy Genetic aspects Kinases Medical prognosis Medical research Metastasis Molecular mechanism Molecular modelling Molecular targets Nanoparticles Osteosarcoma Physiological aspects Review Sarcoma Stem cells Therapeutic applications Therapeutic targets
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and poor overall prognosis mainly in children and adolescents. Identifying the molecular mechanisms and OS stem cells (OSCs) as new concepts involved in disease pathogenesis and progression may potentially lead to new therapeutic targets. Therefore, therapeutic targeting of OSCs can be one of the most important and effective strategies for the treatment of OS. This review describes the new molecular targets of OS as well as novel therapeutic approaches in the design of future investigations and treatment.
ISSN:	1475-2867 1475-2867
DOI:	10.1186/s12935-018-0654-4