Relation between intra-abdominal pressure and early intestinal ischemia in rats

BackgroundLittle is known on early irreversible effects of increased intra-abdominal pressure (IAP). Therefore, timing of abdominal decompression among patients with abdominal compartment syndrome remains challenging. The study objective was to determine the relation between IAP and respiratory parameters, hemodynamic parameters, and early intestinal ischemia.MethodsTwenty-five anesthetized and ventilated male Sprague-Dawley rats were randomly assigned to five groups exposed to IAPs of 0, 5, 10, 15, or 20 mm Hg for 3 hours. Respiratory parameters, hemodynamic parameters, and serum albumin-cobalt binding (ACB) capacity as measure for systemic ischemia were determined. Intestines were processed for histopathology.ResultsIAP was negatively associated with mean arterial pressure at 90 (Spearman correlation coefficient; Rs=−0.446, p=0.025) and 180 min (Rs=−0.466, p=0.019), oxygen saturation at 90 min (Rs=−0.673, p