ITGA4 gene methylation status in chronic lymphocytic leukemia

We aimed to investigate gene expression pattern and to explore its methylation heterogeneity in chronic lymphocytic leukemia (CLL). Eighty one CLL patients and 75 healthy subjects were enrolled and prognostic evaluation of patients was assessed. q-realtime PCR was performed using Applied Biosystems,...

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Veröffentlicht in:	Future science OA 2020-08, Vol.6 (7), p.FSO583-FSO583
Hauptverfasser:	Attia, Hanaa Rm, Ibrahim, Mona Hamed, El-Aziz, Shereen H Abd, Hassan, Naglaa M, Osman, Randa A, Hagag, Heba A, Yassa, Marianne E, Abdelrahman, Amany H, Salama, Iman I, Sobeih, Mohamed Emam
Format:	Artikel
Sprache:	eng
Schlagworte:	beta 2 microglobulin chronic lymphocytic leukemia cytogenetics ITGA4 gene expression methylation analysis prognostic markers
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Beschreibung
Zusammenfassung:	We aimed to investigate gene expression pattern and to explore its methylation heterogeneity in chronic lymphocytic leukemia (CLL). Eighty one CLL patients and 75 healthy subjects were enrolled and prognostic evaluation of patients was assessed. q-realtime PCR was performed using Applied Biosystems, TaqMan gene expression assay. gene-specific CpG methylation was investigated in real time using pyrosequencing technology. was differentially expressed in CLL patients. The CpG sites-1, 2 and 3 showed significantly higher mean levels than healthy controls (p =
ISSN:	2056-5623 2056-5623
DOI:	10.2144/fsoa-2020-0034