Four New Pterosins from Pteris cretica and Their Cytotoxic Activities

Phytochemical investigation of the aerial parts of led to the isolation and elucidation of nine pterosins, including four new pterosins, creticolacton A ( ), 13-hydroxy-2( ),3( )-pterosin L ( ), creticoside A ( ), and spelosin 3- -β-d-glucopyranoside ( ), together with five known pterosins - . Their structures were identified mainly on the basis of 1D and 2D NMR spectral data, ESI-MS and literature comparisons. Compounds and were new type of petrosins with a six membered ring between C-14 and C-15. The new compounds were tested in vitro for their cytotoxic activities against four human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, Lovo). Results showed that compounds and exhibited cytotoxic activity against HCT-116 cells with IC value of 22.4 μM and 15.8 μM, respectively.