Applications of MR fiber tractography imaging in multiple scleros

To evaluate role of fiber tractography in the assessment of white matter (WM) fiber tract affection in patient with multiple sclerosis (MS). Using fiber tractography, WM tract fibers were evaluated in 12 patients with MS and 8 healthy controls in correlation with motor disability in variants of MS, ages range 35–50years, mean 40.9±5.2. MRI imaging was obtained by using 1.5T whole-body scanner. Fiber tractography was acquired after routine sequences. Data postprocessing and fiber tracking method were applied including fractional anisotropy (FA) and mean diffusivity (MD) for three regions. Bilateral WM tract fiber affection was detected in 7 patients, however only 3 showed left sided lesion and 2 patients on right side. WM tract fiber was decreased in all patients; FA and MD for patients were significantly lowered compared to control on all regions (mean values of control FA=1.07±0.34, MD=1.27±0.36, with P