Influence of maternal dexamethasone treatment on morphometric characteristics of pituitary GH cells and body weight in near-term rat fetuses

Influence of maternal dexamethasone treatment on morphometric characteristics of pituitary GH cells and body weight in near-term rat fetuses

Growth hormone (GH) and glucocorticoids have a powerful influence on controlling fetal growth, differentiation and maturation of numerous tissues. In the present study, the effect of maternal dexamethasone (Dx) treatment on GH cells and body weight in 19- and 21-day-old rat fetuses was investigated...

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Veröffentlicht in:Folia histochemica et cytobiologica 2007-01, Vol.45 (1), p.51-56
Hauptverfasser: Manojlović-Stojanoski, M, Nestorović, N, Negić, N, Filipović, B, Sosić-Jurjević, B, Sekulić, M, Milosević, V
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Body Weight - drug effects
Cell Size
Dexamethasone - administration & dosage
Dexamethasone - pharmacology
Female
Fetal Development - drug effects
Fetus - drug effects
Fetus - physiology
Male
Pituitary Gland - embryology
Pregnancy
Rats
Rats, Wistar
Somatotrophs - cytology
Somatotrophs - drug effects
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Zusammenfassung:Growth hormone (GH) and glucocorticoids have a powerful influence on controlling fetal growth, differentiation and maturation of numerous tissues. In the present study, the effect of maternal dexamethasone (Dx) treatment on GH cells and body weight in 19- and 21-day-old rat fetuses was investigated using immunocytochemical and morphometric methods. Pregnant female rats received daily injections of 1.0-0.5-0.5 mg Dx/kg b.w. on days 16-18 of pregnancy (experimental group), while the control group received an equal volume of saline. Dx treatment of pregnant rats enhanced immunostaining intensity and significantly increased (p
ISSN:0239-8508
1897-5631
DOI:10.5603/4552