Baseline gut microbiome impacts probiotics Bacillus licheniformis CMCC63516 in modulating the gut microbiome and preventing antibiotic‐associated diarrhea: A double‐blind, randomized controlled trial

SEE PDF] Permutational multivariate analysis of variance indicated that baseline GM structures and probiotic supplementation contributed to genus- and species-level dissimilarity notably (at genus level, p-value = .001 and .032 for baseline GM cluster and probiotics, respectively; at species level, p-value = .001 and .053 respectively; Figure 3A,B). [...]this study suggests the impact of preexisting GM on the protection of probiotics against AAD and implies the necessity of considering preexisting GM structures when assessing clinical efficacy of probiotics in AAD prevention. FUNDING INFORMATION Shenzhen Key Medical Discipline construction Fund, Grant Number: SZXK032; Scientific Research Foundation of Peking University Shenzhen Hospital, Grant Number: KYQD2021075 Gibson MK, Crofts TS, Dantas G. Antibiotics and the developing infant gut microbiota and resistome.