Decreased serum concentrations of antiseizure medications in children with drug resistant epilepsy following treatment with ketogenic diet

Decreased serum concentrations of antiseizure medications in children with drug resistant epilepsy following treatment with ketogenic diet

Objective To examine the potential influence of a ketogenic diet on serum concentrations of antiseizure medications (ASMs) in children with drug resistant epilepsy. Methods We investigated the serum concentrations of ASMs in 25 children with drug resistant epilepsy, 2–13 years of age, treated with a...

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Veröffentlicht in:Epilepsia open 2023-09, Vol.8 (3), p.858-866
Hauptverfasser: Pedersen, Sigrid, Kverneland, Magnhild, Rudi, Knut, Gervin, Kristina, Landmark, Cecilie Johannessen, Iversen, Per Ole, Selmer, Kaja Kristine
Format: Artikel
Sprache:eng
Schlagworte:
antiseizure medications
Caregivers
Chromatography
Convulsions & seizures
Demographics
Diet
dietary treatment
Epilepsy
Etiology
Fasting
food‐drug interactions
Glucose
high‐fat
low‐carbohydrate diet
Meals
Original
Ostomy
Patients
Recipes
Surgery
therapeutic drug monitoring
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Zusammenfassung:Objective To examine the potential influence of a ketogenic diet on serum concentrations of antiseizure medications (ASMs) in children with drug resistant epilepsy. Methods We investigated the serum concentrations of ASMs in 25 children with drug resistant epilepsy, 2–13 years of age, treated with a classical ketogenic diet for 12 weeks. The patients were recruited from the National Centre for Epilepsy from August 15th, 2017, to January 24th, 2022. Changes in ASM serum concentrations were analyzed using a mixed effect model analysis. Significance level was set at P 
ISSN:2470-9239
2470-9239
DOI:10.1002/epi4.12746